If you are trying to install python-fuse on Mac OS you’ll notice it fails, even with brew. There is an open pull request that fixes this, for both FreeBSD and Mac OS.

It would be nice to see this fix included, in the mean time you can use the fork at https://github.com/mezantrop/python-fuse. Go back to the traditional python setup.py build and python setup.py install and you’ll be set.

I’ve been using it with Python3 on Mac OS 10.13.6 just fine.